ESR 11: Elisabete Cristina Cardoso Mendes Moura
Targeting the Lipopolysaccharide transport to develop novel antimicrobial drugs
Elisabete will develop tools to set up genetic and biochemical screens to identify compounds/molecules that inhibit the assembly of the Lpt multiprotein machinery. The identified molecules will also be used as probes to structurally characterize the target protein(s) by defining their mode of action. Possible resistance mechanisms will also be explored
University of Milano, Department of Pharmacological and Biomolecular Sciences, Italy
Prof. Alessandra Polissi (UNIMI)
Prof. Jean-Pierre Simorre (CNRS)
Prof. Antonio Molinaro (UNINA)
Elisabete holds a Master in Pharmaceutical Sciences obtained at the Oporto University, Oporto (Portugal) in 2015. At her home university, she voluntarily performed research at the Department of Chemical Sciences being involved in projects that aimed to quantify drugs in wastewaters. In 2014, she did an eight-month Erasmus placement at the Department of Membrane Biochemistry and Biophysics of Utrecht University (The Netherlands) in the group of Eefjan Breukink, where she developed a protocol for the purification of MraY, a membrane protein involved in the peptidoglycan biosynthetic pathway. In 2017, she joined Polissi’s team to start a PhD. Her research focuses on the assembly mechanisms of the Lpt machinery and on setting up genetic screens to identify assembly inhibitors.