ESR 7: Elisa Consoli
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Assembly and dynamics of the outer membrane protein inserting BAM machinery and its coordination with peptidoglycan (PG) synthetic machineries
Elisa will determine whether BAM is a permanent or a dynamic complex by analysing the interactome of the BAM complex and checking dependency on substrate for Bam assembly. She will be tasked with assessing whether BAM complex and PG synthetic machineries are able to monitor each other functioning and setting up an in vivo screening assay that reports on the block of outer membrane proteins assembly pathway. |
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Host:
University of Amsterdam, Swammerdam Institute for Life Sciences, The Netherlands Supervisory Team: Prof. Tanneke den Blaauwen (UvA) Prof. Jean-François Collet (UCL) Prof. Jean-Pierre Simorre (CNRS) Scientific Background: Elisa Consoli has a Bachelor of Science's Degree in Biology University of Rome “Tor Vergata” and a Master of Science's Degree in Genetics and Molecular Biology in Basic and Biomedic Research. Her master thesis and internship concerned the conversion of Terminally Differentiated (TD) cells into cell that are able to reenter the cell cycle and differentiate. TD are defined as cellular type that, in order to acquire specialized functions, have irreversibly lost their ability to proliferate. Understanding the mechanisms that cause permanent loss of proliferative capacity in TD cells is a scientific challenge of fundamental interest and practical consequence. TD cells can be forced to re-enter in the cell cycle, but the DNA synthesis appeared to be incomplete due to a structural obstruction in the DNA. Elisa discovered this obstruction by a combination of fluorescence microscopy of labelled DNA and radioactive label incorporation and dot blotting. Science Slam: Introducing BAM created by Elisa and Kara. |
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